Searching for conserved non-coding sequences by comparative genomics is a valuable tool …

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Biology Articles » Evolutionary Biology » Comparative Genomics » Comparative genomics and experimental promoter analysis reveal functional liver-specific elements in mammalian hepatic lipase genes » Conclusion

Conclusion

- Comparative genomics and experimental promoter analysis reveal functional liver-specific elements in mammalian hepatic lipase genes

In summary, we have shown here that a global multispecies comparison of non-coding sequences, followed by a search for conserved clusters of TFBS, has predicted the most important sequences involved in basal transcription of the HL gene. This in silico analysis does not identify all regulatory sequences in a particular gene, but enables the intelligent design of experiments towards identification of functional cis-regulatory elements and transactivating factors in gene regulation. This study illustrates the power of comparative genomics in the identification of TFBS that are functional in gene expression.