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Comparative oncology is a branch of comparative pathology that is relatively new …


Biology Articles » Evolutionary Biology » Comparative Oncology and Comparative Tumor Immunology » Conclusion

Conclusion
- Comparative Oncology and Comparative Tumor Immunology

The biological phenomena whose mechanisms are, at present, explored and largely understood, certainly had their own evolution. Searching for the origin and details of the evolution of "advanced solutions" as well as selection pressures that might justify their emergence and existence, we often fail to see that many such phenomena are, in fact, co-evolutionary byproducts of "evolutionary innovations". In other words, the evolutionary emergence of "advanced solutions" is sometimes, if not always, accompanied by certain by-products and by the co-evolution of compensatory mechanisms acting as a counterbalance to these. An example of the evolution of "advanced solutions" is the evolution of adaptive immunity, and co-evolution of auto-immunity and alloimmunity. Alongside with the diversification of the mechanisms of adaptive immunity, auto-immunity and alloimmunity gain attribute of the evolutionary byproducts and become sources of selection pressure. To that effect, alloimmunity could be a source of very strong selection pressure in mammals, simply because it is directly connected with the reproductive efficacy. At the same time, new forms of selection pressure that are connected with adaptive immunity gave rise to new mechanisms controlling killer machinery of the immune system. Finally, the last in a line of byproducts in the processes of evolutionary "modelling" and "re-modelling" of vertebrate immune system can be called the failure of anti-tumor immunity.

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