The author introduce the regulatory system of biological rhythm from viewpoints of …

• Abstract
• Introduction
• Biological Clock
• Chronotherapy
• Influence of Biological Rhythms on Physiological Function and Diseases
• Influence of Biological Rhythms on Pharmacokinetics and Pharmacodynamics
• Influence of Drugs and Environmental Factors on Biological Rhythms: Adjustment and Manipulation of Rhythms
• Influence of Drugs on Biological Rhythms: Disruption of Rhythms
• Conclusions
• References
• Figures
• Table

Biology Articles » Chronobiology » Chronopharmacology Focused on Biological Clock » Conclusions

Conclusions

- Chronopharmacology Focused on Biological Clock

Many drugs are still given without regard to the time of day. Identiˆcation of a rhythmic marker for selecting dosing time will lead to improved progress and diŠusion of chronopharmacotherapy. To monitor rhythmic markers such as clock genes it may be useful to choose the most appropriate time of day for administration of drugs that may increase their therapeutic eŠects andWor reduce their side eŠects. Furthermore, to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs appears to lead to a new concept of chronopharmacotherapy. Attention should be paid to the alteration of clock gene expression and to consider it an adverse eŠect when it leads to altered regulation of the circadian system, which is a serious problem aŠecting basic functioning of living organisms. One approach to increasing the e‹ciency of pharmacotherapy is administering drugs at times during which they are best tolerated.