..................................................
Table 1. Demographic Characteristics
| Characteristic |
Lactating without calcium supplementation (n = 135) |
Lactating with calcium supplementation (n = 139) |
Nonlactating (n = 153) |
|
| Age (y) |
29 ± 3 |
30 ± 3 |
30 ± 4 |
| Height (cm) |
166 ± 7 |
165 ± 8 |
168 ± 6 |
| Weight (kg) |
69 ± 8 |
67 ± 9 |
67 ± 10 |
| Body mass index (kg/m2) |
25.1 ± 1.8 |
24.4 ± 1.7 |
25.2 ± 1.4 |
| Parity |
1.4 ± 0.8 |
1.6 ± 1 |
1.7 ± 0.9 |
| Baseline BMD at radius (g/cm2) |
0.469 ± 0.009 |
0.489 ± 0.008 |
0.492 ± 0.008 |
| Baseline BMD at spine (g/cm2) |
1.239 ± 0.018 |
1.220 ± 0.014 |
1.211 ± 0.025 |
|
| BMD = bone mineral density. |
| Data are presented as mean ± standard deviation. |
|
..................................................
Table 2. Bone Mineral Density Percent Changes in the Spine* and Radius
| Calcium status and test location |
3 mo |
6 mo |
7 mo |
12 mo |
18 mo |
|
| Lactating without calcium supplementation |
| Spine |
-3.7 ± 0.3 |
-4.4 ± 0.4 |
-3.4 ± 0.3 |
+0.4 ± 0.3 |
+1.8 ± 0.4 |
| Radius |
-1.7 ± 0.2 |
-2.2 ± 0.4 |
-1.6 ± 0.3 |
+0.5 ± 0.3 |
+1.3 ± 0.4 |
| Lactating with calcium supplementation |
| Spine |
-3.4 ± 0.4 |
-4.0 ± 0.3 |
-2.9 ± 0.4 |
+0.8 ± 0.3 |
+2.0 ± 0.4 |
| Radius |
-1.4 ± 0.3 |
-2.0 ± 0.3 |
-1.3 ± 0.4 |
+0.3 ± 0.3 |
+1.3 ± 0.4 |
| Nonlactating |
| Spine |
+0.8 ± 0.4 |
+1.4 ± 0.3 |
|
+2.1 ± 0.3 |
+1.9 ± 0.4 |
| Radius |
+0.4 ± 0.2 |
+0.9 ± 0.3 |
|
+1.1 ± 0.4 |
+1.1 ± 0.3 |
|
| Data are presented as mean ± standard deviation. |
| * Spine mineral density: Model r2 = 0.66, model P = .001; study group P = .001 (lactating with calcium versus lactating without calcium P = .162; nonlactating versus lactating without calcium P = .001; lactating with calcium versus nonlactating P = .001); time P = .001 (Bonferroni correction applied). |
Radius mineral density: Model r2 = 0.59, model P = .001; study group P = .001 (lactating with calcium versus lactating without calcium P = .162; nonlactating versus lactating without calcium P = .001; lactating with calcium versus nonlactating P = .001); time P = .001 (Bonferroni correction applied). |
|
..................................................
Table 3. Bone Mineral Density Percent Changes in Lactating Women According to Return of Menstruation
| |
3 mo
|
|
|
|
|
|
|
| |
Spine |
Radius |
Mo of amenorrhea |
|
6 mo |
7 mo |
12 mo |
18 mo |
|
| Lactating without calcium supplementation |
-3.7 ± 0.4 |
-1.7 ± 0.4 |
|
Spine |
-3.0 ± 0.3 |
-2.0 ± 0.4 |
+0.8 ± 0.3 |
+1.9 ± 0.4 |
| (n = 135) |
(n = 135) |
(n = 135) |
5 |
|
(n = 77) |
(n = 77) |
(n = 77) |
(n = 65) |
| |
|
|
|
Radius |
-1.3 ± 0.3 |
-0.6 ± 0.4 |
+0.7 ± 0.3 |
+1.5 ± 0.4 |
| |
|
|
|
|
(n = 77) |
(n = 77) |
(n = 77) |
(n = 65) |
| |
|
|
|
Spine |
-5.8 ± 0.4 |
-4.8 ± 0.3 |
-0.4 ± 0.4 |
+1.7 ± 0.3 |
| |
|
|
>5 |
|
(n = 58) |
(n = 58) |
(n = 58) |
(n = 48) |
| |
|
|
|
Radius |
-3.1 ± 0.4 |
-2.6 ± 0.3 |
-0.6 ± 0.4 |
+1.1 ± 0.3 |
| |
|
|
|
|
(n = 58) |
(n = 58) |
(n = 58) |
(n = 48) |
| Lactating with calcium supplementation |
-3.4 ± 0.3 |
- 1.4 ± 0.3 |
|
Spine |
-2.6 ± 0.4 |
-1.8 ± 0.3 |
-1.0 ± 0.3 |
+2.2 ± 0.4 |
| (n = 139) |
(n = 139) |
(n = 139) |
5 |
|
(n = 80) |
(n = 80) |
(n = 80) |
(n = 70) |
| |
|
|
|
Radius |
-1.0 ± 0.4 |
-0.2 ± 0.3 |
+0.8 ± 0.3 |
+1.1 ± 0.4 |
| |
|
|
|
|
(n = 80) |
(n = 80) |
(n = 80) |
(n = 70) |
| |
|
|
|
Spine |
-5.4 ± 0.3 |
-4.1 ± 0.4 |
-0.2 ± 0.3 |
+1.8 ± 0.3 |
| |
|
|
>5 |
|
(n = 59) |
(n = 59) |
(n = 59) |
(n = 51) |
| |
|
|
|
Radius |
-3.0 ± 0.3 |
-2.4 ± 0.4 |
-0.2 ± 0.3 |
+1.2 ± 0.3 |
| |
|
|
|
|
(n = 59) |
(n = 59) |
(n = 59) |
(n = 51) |
|
| Values are means ± standard deviation. |
| Spine mineral density: Model r2 = 0.80, model P = .001; calcium supplementation P = .252; menses resumption P = .001; time P = .001, qualitative interaction present. |
| Radius mineral density: Model r2 = 0.70, model P = .001; calcium supplementation P = .001; menses resumption P = .001; time P = .001, no interaction retained. Subgroups pairwise comparison in text. |
|
..................................................
Source: Obstetrics & Gynecology 1999;94:52-56.