| Gene |
Step(s) |
Role or Interactions |
Homologuesa (% identity, % similarity) |
|
| APG1/AUT3 |
Induction |
Serine/threonine kinase |
Homo sapiens (32, 48); Mus musculus (32, 48); Caenorhabditis elegans (24, 41); S. pombe (42, 60) |
| APG2 |
Formation and completion |
Associated with Apg9 |
H. sapiens (24, 39); C. elegans (35, 50); S. pombe (22, 41); P. pastoris (28, 45); Drosophila melanogaster (32, 48) |
| APG5 |
Formation and completion |
Apg12 conjugation system |
H. sapiens (23, 41); M. musculus (24, 41); C. elegans (23, 41); S. pombe (29, 50); D. melanogaster (20, 42); Arabidopsis thaliana (24, 42) |
| APG6/VPS30 |
Formation and completion |
Forms a complex with Apg14, Vps34, and Vps15 |
H. sapiens (29, 48); M musculus (30, 47); Rattus norvegicus (27, 44); C. elegans (28, 49); S. pombe (27, 45); D. melanogaster (29, 45); A. thaliana (25, 43); Triticum aestivum (25, 43) |
| APG7/CVT2 |
Formation and completion |
Apg12 and Aut7 conjugation systems (E1) |
H. sapiens (37, 54); M. musculus (38, 54); C. elegans (37, 56); S. pombe (39, 58); P. pastoris (44, 61); D. melanogaster (37, 54); A. thaliana (39, 56) |
| APG9/CVT7/AUT9 |
Formation and completion |
Transmembrane protein associated with Apg2 |
H. sapiens (30, 52); C. elegans (26, 45); S. pombe (38, 57); D. melanogaster (25, 49); A. thaliana (27, 53) |
| APG10 |
Formation and completion |
Apg12 conjugation system (E2) |
C. elegans (22, 44) |
| APG12 |
Formation and completion |
Apg12 conjugation system (UBL) |
H. sapiens (32, 59); M. musculus (31, 58); C. elegans (23, 46); S. pombe (33, 57); D. melanogaster (28, 56); A. thaliana (36, 64) |
| APG13 |
Induction |
Modulates Apg1 activity |
S. pombe (21, 40) |
| APG14 |
Formation and completion |
Forms a complex with Ap6, Vps34, and Vps15 |
Methanococcus jannaschii (28, 51) |
| APG16 |
Formation and completion |
Associates with the Apg12-Apg5 complex |
|
| APG17 |
Induction (autophagy specific) |
Probably involved in the Apg1-Apg13 interaction |
S. pombe (21, 45); Candida albicans (20, 39) |
| AUT1/APG3 |
Formation and completion |
Aut7 conjugation system (E2) |
H. sapiens (32, 45); M. musculus (32, 44); R. norvegicus (32, 44); C. elegans (35, 50); S. pombe (34, 54); D. melanogaster (32, 48); A. thaliana (32, 44) |
| AUT2/APG4 |
Formation and completion |
Aut7 conjugation system |
H. sapiens (28, 44), (26, 40), (27, 42); C. elegans (26, 40); S. pombe (29, 48); D. melanogaster (28, 42), (29, 45); A. thaliana (29, 44) |
| AUT4 |
Vesicle breakdown (autophagy specific) |
Transmembrane protein |
S. pombe (23, 46); S. coelicolor (25, 41); Bacillus subtilis (20, 40); Clostridium acetobutylicum (20, 40) |
| AUT7/APG8/CVT5 |
Formation and completion |
Aut7 conjugation system (UBL) |
H. sapiens (55, 78), (55, 77), (54, 77); Bos taurus (55, 78); M. musculus (55, 78), (55, 77), (54, 77); R. norvegicus (55, 78), (55, 77); Cavia porcellus (54, 77); C. elegans (53, 74), (34, 64); S. pombe (73, 88); D. melanogaster (56, 78), (54, 76); A. thaliana (73, 90), (71, 84), (71, 86), (65, 80), (70, 85), (76, 90), (54, 75), (49, 73); Laccaria bicolor (76, 90); Gillichthys mirabilis (55, 75) |
| CVT9 |
Induction (Cvt pathway and pexophagy specific) |
Associated with Apg1 |
S. pombe (26, 44); P. pastoris (24, 42) |
| CVT17/AUT5 |
Vesicle breakdown |
Putative transmembrane lipase |
S. pombe (45, 63); C. albicans (48, 62); Cladosporium fulvum (38, 54) |
| CVT18 |
Formation and completion |
|
H. sapiens (27, 43), (30, 45), (26, 45), (28, 44); C. elegans (27, 44), (26, 43), (25, 43); S. cerevisiae (28, 44), (26, 45); S. pombe (33, 50), (26, 46), (26, 44); Neurospora crassa (34, 52); D. melanogaster (25, 42), (25, 42), (23, 40); A. thaliana (30, 51), (41, 60); Oryza sativa (39, 59) |
| CVT19 |
Induction (?) and cargo packaging (Cvt pathway specific) |
Ape1 and Ams1 receptor |
S. cerevisiae (28, 44) |
| VAC8 |
Induction (Cvt pathway and pexophagy specific) |
Associated with Apg13 |
S. pombe (64, 80) |
|
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